Cover Image

Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma

Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the po...

Full description

Saved in:
Bibliographic Details
Main Authors: Figl, Adina (Author) , Scherer, Dominique (Author) , Nagore, Eduardo (Author) , Lorenzo Bermejo, Justo (Author) , Botella-Estrada, Rafael (Author) , Gast, Andreas (Author) , Thirumaran, Ranjit Kumar (Author) , Planelles, Dolores (Author) , Hemminki, Kari (Author) , Schadendorf, Dirk (Author) , Kumar, Rajiv (Author)
Format: Article (Journal)
Language:English
Published: 26 June 2010
In: Mutation research. Genetic toxicology and environmental mutagenesis
Year: 2010, Volume: 702, Issue: 1, Pages: 8-16
ISSN:1388-2120
DOI:10.1016/j.mrgentox.2010.06.011
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mrgentox.2010.06.011
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub
Get full text
Author Notes:Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar

MARC

LEADER 00000caa a2200000 c 4500
001 1871820847
003 DE-627
005 20240311120931.0
007 cr uuu---uuuuu
008 231204s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.mrgentox.2010.06.011  |2 doi 
035 |a (DE-627)1871820847 
035 |a (DE-599)KXP1871820847 
035 |a (OCoLC)1425872960 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Figl, Adina  |d 1975-  |e VerfasserIn  |0 (DE-588)1146398816  |0 (DE-627)1005834245  |0 (DE-576)186024819  |4 aut 
245 1 0 |a Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma  |c Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 
264 1 |c 26 June 2010 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 04.12.2023 
520 |a Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. 
650 4 |a DNA Repair 
650 4 |a DNA-Binding Proteins 
650 4 |a Female 
650 4 |a Humans 
650 4 |a Kinesins 
650 4 |a Male 
650 4 |a Melanoma 
650 4 |a Polymorphism, Single Nucleotide 
650 4 |a Skin Neoplasms 
700 1 |a Scherer, Dominique  |d 1978-  |e VerfasserIn  |0 (DE-588)140126090  |0 (DE-627)616036647  |0 (DE-576)314697233  |4 aut 
700 1 |a Nagore, Eduardo  |e VerfasserIn  |0 (DE-588)1256183237  |0 (DE-627)1800355742  |4 aut 
700 1 |a Lorenzo Bermejo, Justo  |d 1972-  |e VerfasserIn  |0 (DE-588)124754619  |0 (DE-627)706705572  |0 (DE-576)294483632  |4 aut 
700 1 |a Botella-Estrada, Rafael  |e VerfasserIn  |4 aut 
700 1 |a Gast, Andreas  |e VerfasserIn  |0 (DE-588)1226448496  |0 (DE-627)1747463841  |4 aut 
700 1 |a Thirumaran, Ranjit Kumar  |d 1978-  |e VerfasserIn  |0 (DE-588)132214466  |0 (DE-627)519239571  |0 (DE-576)299010074  |4 aut 
700 1 |a Planelles, Dolores  |e VerfasserIn  |4 aut 
700 1 |a Hemminki, Kari  |d 1947-  |e VerfasserIn  |0 (DE-588)1150735872  |0 (DE-627)1010964402  |0 (DE-576)172043751  |4 aut 
700 1 |a Schadendorf, Dirk  |d 1960-  |e VerfasserIn  |0 (DE-588)11142576X  |0 (DE-627)499566076  |0 (DE-576)289702275  |4 aut 
700 1 |a Kumar, Rajiv  |d 1955-  |e VerfasserIn  |0 (DE-588)1164253425  |0 (DE-627)1028811942  |0 (DE-576)508469805  |4 aut 
773 0 8 |i Enthalten in  |t Mutation research. Genetic toxicology and environmental mutagenesis  |d Amsterdam [u.a.] : Elsevier Science, 1997  |g 702(2010), 1 vom: Sept., Seite 8-16  |h Online-Ressource  |w (DE-627)503327336  |w (DE-600)2210272-3  |w (DE-576)25588480X  |x 1388-2120  |7 nnas  |a Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma 
773 1 8 |g volume:702  |g year:2010  |g number:1  |g month:09  |g pages:8-16  |g extent:9  |a Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma 
856 4 0 |u https://doi.org/10.1016/j.mrgentox.2010.06.011  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20231204 
993 |a Article 
994 |a 2010 
998 |g 1164253425  |a Kumar, Rajiv  |m 1164253425:Kumar, Rajiv  |d 50000  |e 50000PK1164253425  |k 0/50000/  |p 11  |y j 
998 |g 11142576X  |a Schadendorf, Dirk  |m 11142576X:Schadendorf, Dirk  |d 50000  |e 50000PS11142576X  |k 0/50000/  |p 10 
998 |g 1226448496  |a Gast, Andreas  |m 1226448496:Gast, Andreas  |d 140000  |e 140000PG1226448496  |k 0/140000/  |p 6 
998 |g 124754619  |a Lorenzo Bermejo, Justo  |m 124754619:Lorenzo Bermejo, Justo  |d 910000  |d 999701  |e 910000PL124754619  |e 999701PL124754619  |k 0/910000/  |k 1/910000/999701/  |p 4 
998 |g 140126090  |a Scherer, Dominique  |m 140126090:Scherer, Dominique  |d 50000  |e 50000PS140126090  |k 0/50000/  |p 2 
998 |g 1146398816  |a Figl, Adina  |m 1146398816:Figl, Adina  |d 60000  |d 61900  |e 60000PF1146398816  |e 61900PF1146398816  |k 0/60000/  |k 1/60000/61900/  |p 1  |x j 
999 |a KXP-PPN1871820847  |e 4425003594 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1871820847","note":["Gesehen am 04.12.2023"],"name":{"displayForm":["Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar"]},"id":{"eki":["1871820847"],"doi":["10.1016/j.mrgentox.2010.06.011"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"origin":[{"dateIssuedDisp":"26 June 2010","dateIssuedKey":"2010"}],"relHost":[{"part":{"volume":"702","text":"702(2010), 1 vom: Sept., Seite 8-16","pages":"8-16","extent":"9","year":"2010","issue":"1"},"titleAlt":[{"title":"Mutation research / Genetic toxicology and environmental mutagenesis"},{"title":"Genetic toxicology and environmental mutagenesis"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Mutation research","title":"Mutation research","partname":"Genetic toxicology and environmental mutagenesis"}],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1997","dateIssuedDisp":"1997-","publisherPlace":"Amsterdam [u.a.]"}],"id":{"eki":["503327336"],"issn":["1388-2120"],"zdb":["2210272-3"]},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["388.1997 -"],"note":["Gesehen am 20.02.20"],"recId":"503327336","disp":"Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanomaMutation research. Genetic toxicology and environmental mutagenesis"}],"person":[{"role":"aut","family":"Figl","display":"Figl, Adina","given":"Adina"},{"family":"Scherer","display":"Scherer, Dominique","given":"Dominique","role":"aut"},{"family":"Nagore","display":"Nagore, Eduardo","given":"Eduardo","role":"aut"},{"role":"aut","given":"Justo","family":"Lorenzo Bermejo","display":"Lorenzo Bermejo, Justo"},{"family":"Botella-Estrada","display":"Botella-Estrada, Rafael","given":"Rafael","role":"aut"},{"display":"Gast, Andreas","family":"Gast","given":"Andreas","role":"aut"},{"role":"aut","family":"Thirumaran","display":"Thirumaran, Ranjit Kumar","given":"Ranjit Kumar"},{"family":"Planelles","display":"Planelles, Dolores","given":"Dolores","role":"aut"},{"role":"aut","given":"Kari","family":"Hemminki","display":"Hemminki, Kari"},{"given":"Dirk","family":"Schadendorf","display":"Schadendorf, Dirk","role":"aut"},{"given":"Rajiv","display":"Kumar, Rajiv","family":"Kumar","role":"aut"}],"physDesc":[{"extent":"9 S."}],"title":[{"title_sort":"Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma","title":"Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma"}]} 
SRT |a FIGLADINASSINGLENUCL2620 

Similar Items