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Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases a...

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Main Authors: Liu, Baoer (Author) , Korkmaz, Brice (Author) , Kraft, Patricia (Author) , Mayer, Tobias (Author) , Sayour, Alex A. (Author) , Grundl, Marc A. (Author) , Domain, Roxane (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author) , Korkmaz-İçöz, Sevil (Author)
Format: Article (Journal)
Language:English
Published: 09 November 2023
In: Journal of translational medicine
Year: 2023, Volume: 21, Pages: 1-12
ISSN:1479-5876
DOI:10.1186/s12967-023-04659-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-023-04659-6
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Author Notes:Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz
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Summary:Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases and oxygen-derived radicals, is associated with adverse graft outcomes. The inhibition of cathepsin C (CatC) has been shown to block NE-related protease activation. We hypothesized that the CatC inhibitor BI-9740 improves graft function after HTX.
Item Description:Gesehen am 13.05.2024
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-023-04659-6

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