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Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases a...

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Hauptverfasser: Liu, Baoer (VerfasserIn) , Korkmaz, Brice (VerfasserIn) , Kraft, Patricia (VerfasserIn) , Mayer, Tobias (VerfasserIn) , Sayour, Alex A. (VerfasserIn) , Grundl, Marc A. (VerfasserIn) , Domain, Roxane (VerfasserIn) , Karck, Matthias (VerfasserIn) , Szabó, Gábor (VerfasserIn) , Korkmaz-İçöz, Sevil (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 09 November 2023
In: Journal of translational medicine
Year: 2023, Jahrgang: 21, Pages: 1-12
ISSN:1479-5876
DOI:10.1186/s12967-023-04659-6
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-023-04659-6
Volltext
Verfasserangaben:Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz
Beschreibung
Zusammenfassung:Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases and oxygen-derived radicals, is associated with adverse graft outcomes. The inhibition of cathepsin C (CatC) has been shown to block NE-related protease activation. We hypothesized that the CatC inhibitor BI-9740 improves graft function after HTX.
Beschreibung:Gesehen am 13.05.2024
Beschreibung:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-023-04659-6

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