Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats
Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases a...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 November 2023
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| In: |
Journal of translational medicine
Year: 2023, Jahrgang: 21, Pages: 1-12 |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/s12967-023-04659-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-023-04659-6
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| Verfasserangaben: | Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz |
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| 520 | |a Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases and oxygen-derived radicals, is associated with adverse graft outcomes. The inhibition of cathepsin C (CatC) has been shown to block NE-related protease activation. We hypothesized that the CatC inhibitor BI-9740 improves graft function after HTX. | ||
| 650 | 4 | |a Cathepsin C | |
| 650 | 4 | |a Heart transplantation | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a Neutrophil elastase | |
| 650 | 4 | |a Reperfusion injury | |
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