Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats
Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases a...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 November 2023
|
| In: |
Journal of translational medicine
Year: 2023, Volume: 21, Pages: 1-12 |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/s12967-023-04659-6 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-023-04659-6
|
| Author Notes: | Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 188829017X | ||
| 003 | DE-627 | ||
| 005 | 20240703174846.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240513s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12967-023-04659-6 |2 doi | |
| 035 | |a (DE-627)188829017X | ||
| 035 | |a (DE-599)KXP188829017X | ||
| 035 | |a (OCoLC)1443675743 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Liu, Baoer |d 1992- |e VerfasserIn |0 (DE-588)1323116672 |0 (DE-627)1883096308 |4 aut | |
| 245 | 1 | 0 | |a Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats |c Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz |
| 264 | 1 | |c 09 November 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.05.2024 | ||
| 520 | |a Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine proteases and oxygen-derived radicals, is associated with adverse graft outcomes. The inhibition of cathepsin C (CatC) has been shown to block NE-related protease activation. We hypothesized that the CatC inhibitor BI-9740 improves graft function after HTX. | ||
| 650 | 4 | |a Cathepsin C | |
| 650 | 4 | |a Heart transplantation | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a Neutrophil elastase | |
| 650 | 4 | |a Reperfusion injury | |
| 700 | 1 | |a Korkmaz, Brice |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kraft, Patricia |e VerfasserIn |0 (DE-588)1241910367 |0 (DE-627)1771802006 |4 aut | |
| 700 | 1 | |a Mayer, Tobias |e VerfasserIn |0 (DE-588)1329118723 |0 (DE-627)1888291419 |4 aut | |
| 700 | 1 | |a Sayour, Alex A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grundl, Marc A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Domain, Roxane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karck, Matthias |d 1961- |e VerfasserIn |0 (DE-588)130833525 |0 (DE-627)505909340 |0 (DE-576)298366169 |4 aut | |
| 700 | 1 | |a Szabó, Gábor |d 1969- |e VerfasserIn |0 (DE-588)1022955152 |0 (DE-627)717338681 |0 (DE-576)366215485 |4 aut | |
| 700 | 1 | |a Korkmaz-İçöz, Sevil |e VerfasserIn |0 (DE-588)1062748697 |0 (DE-627)806830336 |0 (DE-576)420147845 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of translational medicine |d London : BioMed Central, 2003 |g 21(2023), Artikel-ID 799, Seite 1-12 |h Online-Ressource |w (DE-627)369084136 |w (DE-600)2118570-0 |w (DE-576)107015994 |x 1479-5876 |7 nnas |a Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats |
| 773 | 1 | 8 | |g volume:21 |g year:2023 |g elocationid:799 |g pages:1-12 |g extent:12 |a Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s12967-023-04659-6 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240513 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1062748697 |a Korkmaz-İçöz, Sevil |m 1062748697:Korkmaz-İçöz, Sevil |d 910000 |d 910200 |d 50000 |e 910000PK1062748697 |e 910200PK1062748697 |e 50000PK1062748697 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 10 |y j | ||
| 998 | |g 1022955152 |a Szabó, Gábor |m 1022955152:Szabó, Gábor |d 910000 |d 910200 |d 50000 |e 910000PS1022955152 |e 910200PS1022955152 |e 50000PS1022955152 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 9 | ||
| 998 | |g 130833525 |a Karck, Matthias |m 130833525:Karck, Matthias |d 910000 |d 910200 |d 50000 |e 910000PK130833525 |e 910200PK130833525 |e 50000PK130833525 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 1329118723 |a Mayer, Tobias |m 1329118723:Mayer, Tobias |d 50000 |e 50000PM1329118723 |k 0/50000/ |p 4 | ||
| 998 | |g 1241910367 |a Kraft, Patricia |m 1241910367:Kraft, Patricia |d 910000 |d 910200 |e 910000PK1241910367 |e 910200PK1241910367 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1323116672 |a Liu, Baoer |m 1323116672:Liu, Baoer |d 50000 |e 50000PL1323116672 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN188829017X |e 4522157207 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats","title":"Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats"}],"physDesc":[{"noteIll":"Illustrationen","extent":"12 S."}],"person":[{"given":"Baoer","roleDisplay":"VerfasserIn","family":"Liu","role":"aut","display":"Liu, Baoer"},{"family":"Korkmaz","given":"Brice","roleDisplay":"VerfasserIn","display":"Korkmaz, Brice","role":"aut"},{"display":"Kraft, Patricia","role":"aut","family":"Kraft","given":"Patricia","roleDisplay":"VerfasserIn"},{"family":"Mayer","roleDisplay":"VerfasserIn","given":"Tobias","display":"Mayer, Tobias","role":"aut"},{"role":"aut","display":"Sayour, Alex A.","roleDisplay":"VerfasserIn","given":"Alex A.","family":"Sayour"},{"display":"Grundl, Marc A.","role":"aut","family":"Grundl","roleDisplay":"VerfasserIn","given":"Marc A."},{"family":"Domain","roleDisplay":"VerfasserIn","given":"Roxane","display":"Domain, Roxane","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Matthias","family":"Karck","role":"aut","display":"Karck, Matthias"},{"roleDisplay":"VerfasserIn","given":"Gábor","family":"Szabó","role":"aut","display":"Szabó, Gábor"},{"display":"Korkmaz-İçöz, Sevil","role":"aut","family":"Korkmaz-İçöz","given":"Sevil","roleDisplay":"VerfasserIn"}],"relHost":[{"origin":[{"publisherPlace":"London","dateIssuedKey":"2003","publisher":"BioMed Central","dateIssuedDisp":"2003-"}],"disp":"Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in ratsJournal of translational medicine","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"369084136","pubHistory":["1.2003 -"],"note":["Gesehen am 22.06.20"],"id":{"issn":["1479-5876"],"eki":["369084136"],"zdb":["2118570-0"]},"language":["eng"],"part":{"text":"21(2023), Artikel-ID 799, Seite 1-12","volume":"21","extent":"12","pages":"1-12","year":"2023"},"title":[{"title_sort":"Journal of translational medicine","title":"Journal of translational medicine"}],"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz"]},"note":["Gesehen am 13.05.2024"],"language":["eng"],"id":{"eki":["188829017X"],"doi":["10.1186/s12967-023-04659-6"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"188829017X","origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"09 November 2023"}]} | ||
| SRT | |a LIUBAOERKOPHARMACOLO0920 | ||