Effective reprogramming of patient-derived M2-polarized glioblastoma-associated mcroglia/macrophages by treatment with GW2580

Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages and microglial cells (GAM) has great potential to improve patient outcomes. Colonystimulating factor-1 receptor (CSF1R) has emerged as a promising target for reprograming anti-inflammatory M2-like GAMs....

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Hauptverfasser: Fermi, Valentina (VerfasserIn) , Warta, Rolf (VerfasserIn) , Wöllner, Amélie (VerfasserIn) , Lotsch, Catharina (VerfasserIn) , Jassowicz, Lena (VerfasserIn) , Rapp, Carmen (VerfasserIn) , Knoll, Maximilian (VerfasserIn) , Jungwirth, Gerhard (VerfasserIn) , Jungk, Christine (VerfasserIn) , Dao Trong, Huy Philip (VerfasserIn) , Deimling, Andreas von (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Unterberg, Andreas (VerfasserIn) , Herold-Mende, Christel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 14, 2023
In: Clinical cancer research
Year: 2023, Jahrgang: 29, Heft: 22, Pages: 4685-4697
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-23-0576
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-23-0576
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/clincancerres/article/29/22/4685/729949/Effective-Reprogramming-of-Patient-Derived-M2
Volltext
Verfasserangaben:Valentina Fermi, Rolf Warta, Amélie Wöllner, Catharina Lotsch, Lena Jassowicz, Carmen Rapp, Maximilian Knoll, Gerhard Jungwirth, Christine Jungk, Philip Dao Trong, Andreas Von Deimling, Amir Abdollahi, Andreas Unterberg, and Christel Herold-Mende
Beschreibung
Zusammenfassung:Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages and microglial cells (GAM) has great potential to improve patient outcomes. Colonystimulating factor-1 receptor (CSF1R) has emerged as a promising target for reprograming anti-inflammatory M2-like GAMs. However, treatment data on patient-derived, tumor-educated GAMs and their influence on the adaptive immunity are lacking.
Beschreibung:Gesehen am 13.05.2024
Beschreibung:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-23-0576