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Low serum vitamin D status is associated with incident Alzheimer’s dementia in the oldest old

Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-pr...

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Main Authors: Melo van Lent, Debora (Author) , Egert, Sarah (Author) , Wolfsgruber, Steffen (Author) , Kleineidam, Luca (Author) , Weinhold, Leonie (Author) , Wagner-Thelen, Holger (Author) , Stoffel-Wagner, Birgit (Author) , Bickel, Horst (Author) , Wiese, Birgitt (Author) , Weyerer, Siegfried (Author) , Pentzek, Michael (Author) , Jessen, Frank (Author) , Schmid, Matthias (Author) , Maier, Wolfgang (Author) , Scherer, Martin (Author) , Riedel-Heller, Steffi G. (Author) , Ramirez, Alfredo (Author) , Wagner, Michael (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Nutrients
Year: 2023, Volume: 15, Issue: 1, Pages: 1-15
ISSN:2072-6643
DOI:10.3390/nu15010061
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/nu15010061
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6643/15/1/61
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Author Notes:Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. Riedel-Heller, Alfredo Ramirez and Michael Wagner
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Summary:Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
Item Description:Online veröffentlicht: 23. December 2022
Gesehen am 06.08.2024
Physical Description:Online Resource
ISSN:2072-6643
DOI:10.3390/nu15010061

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