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Urinary Dickkopf-related protein 3 as a novel biomarker for kidney function decline in children with Alport syndrome

Chronic kidney disease (CKD) seriously affects the well-being and shortens the life expectancy of children and adolescents, but its progression is challenging to predict. Therefore, there is an urgent need for biomarkers that can identify children at risk of faster CKD progression. Alport syndrome (...

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Main Authors: Böckhaus, Jan Simon (Author) , Tönshoff, Burkhard (Author) , Weber, Lutz T. (Author) , Pape, Lars (Author) , Latta, Kay (Author) , Fehrenbach, Henry (Author) , Lange-Sperandio, Baerbel (Author) , Kettwig, Matthias (Author) , König, Sabine (Author) , John-Kroegel, Ulrike (Author) , Gellermann, Jutta (Author) , Galiano, Matthias (Author) , Jami, Sima (Author) , Pieper, Dennis (Author) , Dihazi, Gry Helene (Author) , Hafke, Angelika (Author) , Kohl, Stefan (Author) , Liebau, Max C. (Author) , König, Jens (Author) , Haffner, Dieter (Author) , Gross, Oliver (Author) , Wallbach, Manuel (Author)
Format: Article (Journal)
Language:English
Published: 4 February 2025
In: Pediatric nephrology
Year: 2025, Volume: 40, Issue: 7, Pages: 2205-2213
ISSN:1432-198X
DOI:10.1007/s00467-025-06696-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00467-025-06696-3
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Author Notes:Jan Boeckhaus, Burkhard Tönshoff, Lutz T. Weber, Lars Pape, Kay Latta, Henry Fehrenbach, Baerbel Lange-Sperandio, Matthias Kettwig, Sabine König, Ulrike John-Kroegel, Jutta Gellermann, Matthias Galiano, Sima Jami, Dennis Pieper, Gry Helene Dihazi, Angelika Hafke, Stefan Kohl, Max C. Liebau, Jens König, Dieter Haffner, Oliver Gross, Manuel Wallbach
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Summary:Chronic kidney disease (CKD) seriously affects the well-being and shortens the life expectancy of children and adolescents, but its progression is challenging to predict. Therefore, there is an urgent need for biomarkers that can identify children at risk of faster CKD progression. Alport syndrome (AS) is the most common monogenetic glomerular kidney disease. Urinary Dickkopf-related protein 3 (DKK3) is associated with a decline in estimated glomerular filtration rate (eGFR) in adults and children with advanced CKD. However, its potential for early detection of CKD and its prognostic value in children with AS remain unknown.
Item Description:Gesehen am 22.10.2025
Physical Description:Online Resource
ISSN:1432-198X
DOI:10.1007/s00467-025-06696-3

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