Cover Image

GDF-15 and uEGF independently associate with CKD progression in children

Introduction - Currently, there is limited ability to predict the progression of chronic kidney disease (CKD) in children. Previously we reported that low levels of urinary epidermal growth factor (uEGF) predict CKD progression in children. In the present study, we investigated a novel serum biomark...

Full description

Saved in:
Bibliographic Details
Main Authors: Bartels, Julia (Author) , Tabatabaeifar, Mansoureh (Author) , Kirchner, Marietta (Author) , Azukaitis, Karolis (Author) , Doyon, Anke (Author) , Bayazit, Aysun (Author) , Düzova, Ali (Author) , Canpolat, Nur (Author) , Bulut, Ipek Kaplan (Author) , Obrycki, Lukasz (Author) , Ranchin, Bruno (Author) , Shroff, Rukshana (Author) , Lugani, Francesca (Author) , Candan, Cengiz (Author) , Harambat, Jerome (Author) , Alpay, Harika (Author) , Litwin, Mieczyslaw (Author) , Jankauskiene, Augustina (Author) , Klaus, Günter (Author) , Drozdz, Dorota (Author) , Montini, Giovanni (Author) , Zurowska, Aleksandra (Author) , Afonso, Alberto Caldas (Author) , Wühl, Elke (Author) , Melk, Anette (Author) , Querfeld, Uwe (Author) , Mehls, Otto (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: October 2025
In: Kidney international. Reports
Year: 2025, Volume: 10, Issue: 10, Pages: 3369-3378
ISSN:2468-0249
DOI:10.1016/j.ekir.2025.07.004
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ekir.2025.07.004
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2468024925004358
Get full text
Author Notes:Julia Bartels, Mansoureh Tabatabaeifar, Marietta Kirchner, Karolis Azukaitis, Anke Doyon, Aysun Bayazit, Ali Düzova, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Bruno Ranchin, Rukshana Shroff, Francesca Lugani, Cengiz Candan, Jerome Harambat, Harika Alpay, Mieczyslaw Litwin, Augustina Jankauskiene, Günter Klaus, Dorota Drozdz, Giovanni Montini, Aleksandra Zurowska, Alberto Caldas Afonso, Elke Wühl, Anette Melk, Uwe Querfeld, Otto Mehls, and Franz Schaefer, on behalf of the 4C Study and ESCAPE Trial Consortia
Description
Summary:Introduction - Currently, there is limited ability to predict the progression of chronic kidney disease (CKD) in children. Previously we reported that low levels of urinary epidermal growth factor (uEGF) predict CKD progression in children. In the present study, we investigated a novel serum biomarker, growth differentiation factor 15 (GDF-15), in 2 European pediatric CKD cohorts. We additionally explored the combined effect of GDF-15 and/or uEGF on CKD progression in children. - Methods - The association between serum GDF-15 levels and CKD progression was analyzed in 671 patients of the Cardiovascular Comorbidity in Children with CKD (4C) study, aged 6 to 17 years with an estimated glomerular filtration rate (eGFR) of 10 to 60 ml/min per 1.73 m2 at baseline, and median follow-up of 8 years. The composite end point was start of kidney replacement therapy, 50% eGFR loss, or eGFR < 10 ml/min per 1.73 m2. Results were validated in 329 participants from the ESCAPE trial. - Results - Higher GDF-15 levels were associated with an increased risk of CKD progression (hazard ratio: 1.40; 95% confidence interval [CI]: 1.10-1.77), independent of age, sex, baseline eGFR, proteinuria, and systolic blood pressure. Whereas adding either GDF-15 or uEGF individually to a model containing these variables improved model fit, combining both markers improved the model further. External validation in the ESCAPE cohort confirmed these results. - Conclusion - Serum GDF-15 and urine EGF levels may provide complementary information on the risk of CKD progression in children and might be included in future prognostic biomarker panels aimed at personalized, risk-stratified management of pediatric CKD.
Item Description:Online verfügbar: 16. Juli 2025, Artikelversion: 8. Oktober 2025
Gesehen am 02.01.2026
Physical Description:Online Resource
ISSN:2468-0249
DOI:10.1016/j.ekir.2025.07.004

Similar Items