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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes that accounts for approximately 15% of pediatric acute lymphoblastic leukemias. A variety of genetic events affecting cellular processes such as the cell cycle, differentiation and survival have been identified in

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Bibliographic Details
Main Authors: Bandapalli, Obul Reddy (Author) , Schüssele, Stephanie (Author) , Kunz, Joachim (Author) , Rausch, Tobias (Author) , Stütz, Adrian M. (Author) , Tal, Noa (Author) , Geron, Ifat (Author) , Gershman, Nava (Author) , Izraeli, Shai (Author) , Eilers, Juliane (Author) , Vaezipour, Nina (Author) , Kirschner-Schwabe, Renate (Author) , Hof, Jana (Author) , Stackelberg, Arend von (Author) , Schrappe, Martin (Author) , Stanulla, Martin (Author) , Zimmermann, Martin (Author) , Köhler, Rolf (Author) , Avigad, Smadar (Author) , Handgretinger, Rupert (Author) , Frismantas, Viktoras (Author) , Bourquin, Jean Pierre (Author) , Bornhauser, Beat (Author) , Korbel, Jan Oliver (Author) , Muckenthaler, Martina (Author) , Kulozik, Andreas (Author)
Format: Article (Journal)
Language:English
Published: October 2014
In: Haematologica
Year: 2014, Volume: 99, Issue: 10, Pages: e188-e192
ISSN:1592-8721
DOI:10.3324/haematol.2014.104992
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2014.104992
Verlag, lizenzpflichtig, Volltext: http://www.haematologica.org/content/99/10/e188
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Author Notes:Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, and Andreas E. Kulozik
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Summary:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes that accounts for approximately 15% of pediatric acute lymphoblastic leukemias. A variety of genetic events affecting cellular processes such as the cell cycle, differentiation and survival have been identified in
Item Description:Gesehen am 20.07.2020
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2014.104992

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