Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background),...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 October 2013
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| In: |
Nature Communications
Year: 2013, Volume: 4, Pages: 1-7 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms3549 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms3549 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms3549 
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| Author Notes: | Matthew Frampton, Miguel Inacio da Silva Filho, Peter Broderick, Hauke Thomsen, Asta Försti, Jayaram Vijayakrishnan, Rosie Cooke, Victor Enciso-Mora, Per Hoffmann, Markus M. Nöthen, Amy Lloyd, Amy Holroyd, Lewin Eisele, Karl-Heinz Jöckel, Sabine Ponader, Elke Pogge von Strandmann, Tracy Lightfoot, Eve Roman, Annette Lake, Dorothy Montgomery, Ruth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Kari Hemminki & Richard S. Houlston |
MARC
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| 520 | |a In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. | ||
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