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Comprehensive genomic and transcriptomic analysis for guiding therapeutic decisions in patients with rare cancers

The clinical relevance of comprehensive molecular analysis in rare cancers is not established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients (rare cancers, 75.5%) enrolled in a prospective observational study by the German Cancer Consortium that applies whole-genome/exom...

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Main Authors: Horak, Peter (Author) , Hutter, Barbara (Author) , Mock, Andreas (Author) , Hüllein, Jennifer (Author) , Gieldon, Laura (Author) , Teleanu, Maria-Veronica (Author) , Heilig, Christoph E. (Author) , Lipka, Daniel (Author) , Allgäuer, Michael (Author) , Endris, Volker (Author) , Neumann, Olaf (Author) , Penzel, Roland (Author) , Wolf, Stephan (Author) , Buchhalter, Ivo (Author) , Hohenberger, Peter (Author) , Kroiß, Matthias (Author) , Schirmacher, Peter (Author) , Schlenk, Richard Friedrich (Author) , Keilholz, Ulrich (Author) , Klauschen, Frederick (Author) , Folprecht, Gunnar (Author) , Siveke, Jens (Author) , Brandts, Christian Hubertus (Author) , Kindler, Thomas (Author) , Börries, Melanie (Author) , Illert, Anna Lena (Author) , Bubnoff, Nikolas von (Author) , Schulze-Osthoff, Klaus (Author) , Kalle, Christof von (Author) , Klink, Barbara (Author) , Brors, Benedikt (Author) , Stenzinger, Albrecht (Author) , Schröck, Evelin (Author) , Hübschmann, Daniel (Author) , Weichert, Wilko (Author) , Glimm, Hanno (Author) , Fröhling, Stefan (Author)
Format: Article (Journal)
Language:English
Published: June 10, 2021
In: Cancer discovery
Year: 2021, Volume: 11, Issue: 11, Pages: 2780-2795
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-21-0126
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/2159-8290.CD-21-0126
Verlag, lizenzpflichtig, Volltext: https://cancerdiscovery.aacrjournals.org/content/early/2021/06/11/2159-8290.CD-21-0126
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Author Notes:Peter Horak, Christoph Heining, Simon Kreutzfeldt, Barbara Hutter, Andreas Mock, Jennifer Hullein, Martina Frohlich, Sebastian Uhrig, Arne Jahn, Andreas Rump, Laura Gieldon, Lino Mohrmann, Dorothea Hanf, Veronica Teleanu, Christoph E. Heilig, Daniel B. Lipka, Michael Allgauer, Leo Ruhnke, Andreas Lassmann, Volker Endris, Olaf Neumann, Roland Penzel, Katja Beck, Daniela Richter, Ulrike Winter, Stephan Wolf, Katrin Pfutze, Christina Georg, Bettina Meissburger, Ivo Buchhalter, Marinela Augustin, Walter E. Aulitzky, Peter Hohenberger, Matthias Kroiss, Peter Schirmacher, Richard F. Schlenk, Ulrich Keilholz, Frederick Klauschen, Gunnar Folprecht, Sebastian Bauer, Jens Thomas Siveke, Christian H. Brandts, Thomas Kindler, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Philipp J. Jost, Karsten Spiekermann, Michael Bitzer, Klaus Schulze-Osthoff, Christof von Kalle, Barbara Klink, Benedikt Brors, Albrecht Stenzinger, Evelin Schrock, Daniel Hubschmann, Wilko Weichert, Hanno Glimm, Stefan Frohling
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Summary:The clinical relevance of comprehensive molecular analysis in rare cancers is not established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients (rare cancers, 75.5%) enrolled in a prospective observational study by the German Cancer Consortium that applies whole-genome/exome and RNA sequencing to inform the care of adults with incurable cancers.
Item Description:Gesehen am 16.06.2021
Physical Description:Online Resource
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-21-0126

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