DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy

DNA repair plays an important role in chemoresistance to platinum-based therapy, and therefore polymorphisms in the genes may modulate therapeutic response. We assessed 12 polymorphisms in 7 DNA repair genes and 2 polymorphisms in the MTHFR gene for association with disease response and prognosis.

Bibliographic Details

Main Authors:	Ott, Katja (Author) , Rachakonda, P. Sivaramakrishna (Author) , Panzram, Benjamin (Author) , Keller, Gisela (Author) , Lordick, Florian (Author) , Becker, Karen (Author) , Langer, Rupert (Author) , Büchler, Markus W. (Author) , Hemminki, Kari (Author) , Kumar, Rajiv (Author)
Format:	Article (Journal)
Language:	English
Published:	24 February 2011
In:	Annals of surgical oncology Year: 2011, Volume: 18, Issue: 9, Pages: 2688-2698
ISSN:	1534-4681
DOI:	10.1245/s10434-011-1601-y
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1245/s10434-011-1601-y
Author Notes:	Katja Ott, MD, P. Sivaramakrishna Rachakonda, PhD, Benjamin Panzram, PhD, Gisela Keller, MD, Florian Lordick, MD, Karen Becker, MD, Rupert Langer, MD, Markus Buechler, MD, Kari Hemminki, MD, and Rajiv Kumar, PhD